Thus, studies that clearly delineate which histologic parameters serve as the greatest source of disagreement for pathologists provide a valuable framework for further refinement of the criteria for endometrial dating.
Utilizing repeat biopsy and examination by SEM, these cyclical changes allow hormonal manipulation and direct observation of the known morphological characteristics to be used as predictors of uterine receptivity.
In conjunction with these markers, the appearance of uterodomes (pinopods) .
Although dating, and therefore predicting, the state of the secretory epithelium in a 28 day cycle, or with known LH surge, has been well documented, ET is often not successful in a hormonally prepared uterus which cannot otherwise be visualised or assessed.
As the vascularization of the endometrium changes during the menstrual cycle, a dating of the endometrium was made based on the blood vessel pattern. Hysteroscopically we were able to define five different phases in the menstrual cycle: early proliferative, late proliferative, early secretory, late secretory, and premenstrual-menstrual phase.
Histopathological examination confirmed the hysteroscopical diagnosis of the phases in 72, 69.7, 81.3, 53.8 and 70%, respectively.